Kenneth L. Van Golen, PhD
- Associate Professor of Biological Science, University of Delaware
- Senior Research Scientist, Helen F. Graham Cancer Center
- University of Delaware
- Dept. of Biological Sciences
- 320 Wolf Hall
- Newark, DE, 19716
- United States of America
- Phone: 302.831.2669
Research and Clinical Interests
Since 1996, my research has been focused on understanding the biology of Inflammatory Breast Cancer (IBC). In 1999 my laboratory found that RhoC GTPase, a member of the Rho subfamily of the Ras-superfamily of monomeric G-proteins, is overexpressed and active in IBC. RhoC drives the invasive and metastatic capabilities of IBC and is also a prognostic marker for particularly aggressive breast cancers. Much of my research over the years has focused on RhoC biology and its role in IBC progression.
Currently, my laboratory is concerned with studying various aspects of IBC biology with a main focus on what makes this disease so aggressive and invasive. Studies in my laboratory have expanded from focusing on RhoC GTPase to scientific model development, microenvironment interactions, the biology of skin metastases, unique signal transduction pathways and development of new therapeutic agents.
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